![]() Questions raised about confirmatory study completion There were also concerns about safety, including some cardiac and liver reactions. And how to know which patients it might help, and which it wouldn't." "Additional uncertainties have to do with whether of expression of Sarepta's micro-dystrophin is suitable as a surrogate endpoint considered reasonably likely to predict clinical benefit. "Others involve the nonclinical data, the results from animal studies," he added. A process change led to reduced purity for the gene therapy in later production. "Some have to do with the manufacturing," he said. Mike Singer summarized some of the agency's concerns. Tempering these stories, FDA scientists spent more than an hour raising questions about the evidence submitted by Sarepta for the gene therapy.įDA scientist Dr. We cried nearly a quadrillion tears of joy." Hopping up off the ground after sitting or laying on the couch. Racing up stairs, climbing indoor playground equipment, running, jumping. ![]() ![]() Check this out,' showing me live footage of Andrew doing the unexpected. "Or we'd connect over FaceTime and she'd very discreetly whisper, 'Nate, Nate. "Sarah often opened with her excitedly exclaiming: 'You're never going to believe what Andrew just did today,' " he said. Craig McDonald from the University of California, Davis, who testified on behalf of the company, said, "We cannot afford to delay access to this transformational treatment." He said there's evidence micro-dystrophin levels after treatment are a good measure of its effectiveness, and that Sarepta does have preliminary evidence the treatment is, in fact, helpful.ĭuring testimony from the public, Nathan Plasman described calls he'd get from his wife after their son was treated as part of a Sarepta study. ![]() Sarepta presented a complicated mix of results from animal and human studies in support of its application for an accelerated approval of SRP-9001. The company's request for approval rested mainly on how much micro-dystrophin the treatment produces in patients' muscles instead of waiting for clear, real-world evidence that it's actually helping patients. ![]()
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![]() ![]() Moreover, all the brushes in this set are really detailed and of high quality. ![]() You can go from setting up a background to creating the main subject in no time. Stocking Stuffers – Free Background & Texture Brushes Flora: Vegetation Brushes for Procreateġ.Taozipie Skin Details – Free Skin Brushes.Alien Galactic Space Brushes for Procreate.Jingsketch Basic – Free Premium Brushes.Paperlike Dynamic – Free Environment Brush Set.Stocking Stuffers – Free Background & Texture Brushes.Sketching enables you and empowers you to express on paper your ideas and possibilities that come across your imagination. Having the power to tell your story through your ability to sketch, will solidify your brand identity. Learning how to sketch fashion designs, and the practice of it, will give you confidence and certainty it will boost your morale, and the ability to communicate your ideas. Practicing your fashion sketching consistently will enable you to achieve that goal. Fashion brands come and go therefore you must build a strong foundation with a strong particular and different style that you can call your own. Establishing your own style is key in creating a successful brand. Knowing what you like (and don't like) empowers your designing abilities and will support you in developing your unique "voice".ĭeveloping your own unique fashion design style is very important: what makes you different than the next designer. You will learn how to create a "fashion journal" which will help you develop your own unique style as a fashion designer. A Croquis is "taller/longer" than the normal body thus elongating the body/figure and appearing taller than the average human body. You will learn how the industry uses a Template known as the Croquis as a way to sketch ideas. The sketch will eventually become the garment thus needs to be accurate and clear. Your seamstress and/or pattern-maker have to be able to look at your sketches and understand what you're communicating. They have to understand what you are trying to achieve in your design and sketching it correctly is necessary. Whether you are a beginner designer or a professional, sketching plays an important role when delegation responsibilities to your assistant or team. ![]() Learning how the torso and the hips work together in-sync with each other will enable you to sketch dramatic and impressive figures and illustrations.Īs a fashion designer the pencil will become your best friend: learning techniques on how to hold the pencil and apply pressure unto paper in order to achieve different "thickness", applying different weight of the pencil unto paper. That's when learning how to use the Plumb Line correctly will enable you to create your sketches so they look professional and exciting. You will learn that the body moves in a certain way and stays balanced at all times. Being able to share ideas that can eventually be translated into an actual garment is so important. Sketching ideas swirling in your imagination onto paper is the first step in developing a fashion portfolio and a fashion collection/line. Pencil techniques to create "shirring/gathers", and shading, and coloring.Ĭreating a "fashion diary-journal" to use as source of inspiration to influence ideas for designing.ĭifferentiate garment closure between men's wear and women's wear How to use a Croquis as a template to start sketching fashion ideas.īody movement and creating an "S-shaped" silhouette.īalancing the body and use of the Plumb Line. You will learn garment closure: difference between womenswear and menswear button closure. You will also look at inspiration as a way to influence sketching: fashion inspiration, using a "fashion diary/journal" - creating a "pool" from which to draw ideas from will definitely affect your ability to draw new fashion designs. Using the pencil correctly is the foundation of good sketching, whether it's fashion design or not. We start with a simple exercise using a pencil and learn how to achieve different "shading" effects depending on how you are holding the pencil. You will learn the industry standard "9-Heads Croquis". In this Course you will learn how the body moves, body movement, and balancing the body using the Plumb Line. ![]() This Fashion Sketching Course (7-videos-modules) is for beginners: young and old, with an interest and passion for designing fashion. ![]() ![]() ![]() He has two eyes, medium-sized body, and his hair looks neat. The characteristics are not different from other Minions (well, all of them are similar indeed). In the video, he looks panic and screams. You can watch this version on YouTube and Dailymotion. However, he is featured in the short video in the DVD version of Despicable Me entitled Home Makeover. Frank pinterest.atįrank is not seen often just like the four Minions mentioned above. They are when Dave had a fantasy about Lucy and when he disguised into a purple Minion to sneak up into El Macho’s house. There are some memorable scenes that feature Dave. Aside from being good at playing video games, he can create handicrafts from foods. At the same time, Dave is also really careless and, of course, he causes chaos.ĭave is really smart, creative, and talented. He is really kind, charming, and care of others. Yes, he has hair and it is even quite long. He is a medium-sized Minion with two eyes and half-split hair on his head. Sure, he is the most often to accompany Gru his mission in the world. Dave The Minion ĭave is one of the most stand-out Minions mainly in Despicable Me 2. Uniquely, he is polite and well-behaved with other people. Sometimes, his actions cause troubles for Gru and his fellow Minions. He is known for his plan to steal Larry’s banana. He is one of the one-eyed Minions in the movie series. With this medium-sized body, he looks faster and more dexterous compared with others. Darwin ĭarwin’s body is not as tall as Carl but also not as short as Bob. But sure, it makes the entire movies even more funny and interesting. doo”, multiple times so that other Minions just shouted out at him. More than that, he also “sing” along “bee do. Carl even wore red sirens on his head as well as his hand carried a toa. He was the living alarm when his boss, Gru, burned down the phone in the second film. He is more cheerful and easy to get along whether with his fellow Minions or with the human. Compared to Bob, Carl is taller with only one eye. ![]() He acts naturally like a child, very cute for sure but sometimes, annoying. In term of behavior, Bob is a trouble-maker and an attention seeker. Uniquely, he is the only Minion who is suffered from Heterochromia or different irises between the left and right eyes. He is one of some Minions that don’t have any hair at all. The Minion even becomes the youngest king.īob’s body is small, a little bit fat, and bald. He even got some fortunes including being chosen as an employee of Scarlet Overkill. However, it doesn’t mean that the chaos he made is just bad. Meanwhile, in Despicable Me 2’s final credit, he was the one who causes chaos. Bob The Minion īob is one of the three main characters in the films, particularly in the Minions prequel. Here are the list of minion names complete with photo and explanation. At least, there are 24 Minions that are named in Despicable Me. ![]() One of them is to know the name of each Minions. It is not exaggerating if many viewers just fall in love with it and want to know more about the characters. But something that cannot be denied, all of the Minions are super cute and funny. There are so many conspiracy theories and issues behind the films. However, they have the same purpose giving the best services to the most despicable boss in the world making him happy is the main reason why the creatures exist. ![]() The number of this “species” is numerous with little different characteristics. In the films, the narrator said that Minions have been on earth even longer than dinosaurs. Well, it is even if you actually have not watched the movies yet. Minions, everybody must know this cute yellow character in the movie series Despicable Me. ![]() ![]() ![]() Just download them and jump into the battles and goal of achieving game plans. You can enjoy amazing games without the need for a constant internet connection like Vainglory, XCOM, Kingdom Rush, etc. Then you are in the right place to get your hands on the best offline strategy games for Android. We attach great importance to this issue and hope to get more detailed details about this issue, please provide screenshots or screen recordings and send email to We'll solve it as soon as possible.Roaming around the Play Store to find the best offline strategy games? Better if it’s a hybrid of a card game and a strategy game? ![]() As my money is stuck on level 19 with no where to go. I would highly recommend that you don't sink any money into it until fixed. Cant have pay to play with bugs like that and no one available to fix it. But for the support currently in place i rate it a 0. Hope they get it worked out and get a support system as the game is a great glorified chess game. You have to click on the level to remove troops and restart. My Rommel and troops that i purchased are now stuck on level 19 because i cant click on it anymore. Got on the game later and i couldnt click on level 19. Couldnt find support link so I got on the Facebook page and wrote a private message explaining. For example got stuck on normal level 19. Then you look for support and realize they have none. > In the five-year Soviet German War, there were more than one hundred battles and battles, and nearly 50 million people died as a result of this war.įun game but then you start having bug issues. > If you have any problems, please contact us and we will help you solve them ![]() ![]() > We hope to hear more suggestions from you and make this game better > We have better sound effects (solving the copyright problem) > You can login your account to protect your data (next version update) > We will keep updating, but we need to wait patiently > Write in the end, to every commander's sincerity. > Remember to log in to the game everyday to get every reward > Heavy tanks are the king of the battlefield. > Katyusha rockets can scatter and provide covering fire Please don't use them to charge into the enemy ranks > The towed gun needs to rebuild its artillery positionafter moving, so it needs to wait for a round to attack > Maintain your morale and keep your troops out of siege You need more infantry to lay mines, occupy towns and build fortifications. > Building blockhouses at bridgeheads or other intersections can effectively block the enemy > Rendering a more real atmosphere of WW2 > More detailed help system to help you understand each function > Morale system, surround more enemies as much as possible and weaken their morale > Production and construction, reasonable allocation of resources to win the war Will you make the same mistakes as the Germans. As a commander, you need to think more about terrain constraints > Add terrain constraints to simulate a more realistic battlefield. Of course, you can also use the fog to ambush the enemy. > Build your own troop, train and gain experience to upgrade them > Katyusha rockets, unique scattering function, covering the whole battlefield with shell. > Engineer soldiers, lay mines, build blockhouses. > Airborne soldiers, reasonable use of which can reap unexpected results. Can you change the historical outcome of these wars. Minsk Campaign, Kiev Siege, Leningrad Defense War, Moscow Defense War, Mars Plan, and Kurs War. Guderian's Groß deutschland division, Zhukov's Moscow Defense War, as well as the famous trump army Viking Division, “Das Reich” Division, 3rd SS-Panzer-Division Totenkopf. Rommel, Goodrian, Manstein, Zhukov, Konev, Rokosovsky, Vatukin and other famous generals of World War II will show you their unique tactics and their trump card troops. Lead the German army to the east or join the Soviet Union to defend their motherland. In this WW2 game, you will face tasks and challenges from different camps and battlefields at different times. > The game began in 1941 when the German army attacked the Soviet Union. Terrain and generals, arms, troops with any combination, so that all strategy can become possible! New sequel, free offline WW2 strategy game. One of the best World War II strategy games and war games. ![]() ![]() This usually occurs on machines that support High Sierra (macOS 10.13) natively, but whose owners have not installed High Sierra on them previously.
![]() ![]() We'd like to reassure our Community that we're aware of this issue and are actively investigating a fix as a priority. If you’re experiencing a bug in-game, don't forget to submit a support request via our help centre.Īlongside our usual extended patch notes listed below, we'd like to make mention of the increased number of reports we've received for the 12011 connectivity error, specifically impacting connection for some of our Xbox users and those playing with them from other platforms. ![]() Microsoft Platforms - A number of issues have been resolved regarding player attempts to host/join any co-op game, axis invasion, or multiplayer quick match.Players will no longer get the error 12011 message when attempting to join a lobby using a PS4 through browse (and vice versa).Crossplay - Players will no longer get the timeout error 12011 when trying to join each others lobbies via invite code and browse menu.Dedicated Servers - Players will no longer be kicked out of 16-player multiplayers games with error 12011.The ZF41 CQB, T-97 & T-99 scopes are now the correct way round on the TERA rifle.The reload wheel for the TERA rifle is no longer observed appearing twice for players on successfully reloading the rifle after emptying the clip.We’ve just rolled out a number of bug fixes across all platforms to address the incorrect scope placement on the TERA rifle and the widely reported 12011 connectivity error impacting players in multiplayer. ![]() ![]() Guests are responsible for their own transportation to and from Auckland, New Zealand. Two bedrooms are configured, featuring one queen bed, and the other two king-singles. To request to book, guests must have a verified Airbnb profile, a history of positive reviews and be aged 18+. You Shall Not Pass! (without requesting to book, of course). Stays will take place March 2-4, March 9-11, and March 16-18, 2023. Hobbits, elves, wizards and others may request to book one of three overnight stays on Wednesday, December 14 from 10:00AM NZDT at /hobbiton. I am delighted to share the beauty of my family’s farm and pleased to be hosting this iconic location on Airbnb for fans from around the world. No pets are allowed, except Pickles the resident Hobbiton cat.įor more than two decades, we’ve welcomed millions of passionate fans to Hobbiton Movie Set, but never before has anyone had the opportunity to spend a night in Middle-earth.Straying far at night is discouraged, thanks to multiple troll sightings of late.Pony parking is provided only at The Green Dragon Inn.Magical rings permitted, but keep them secret, keep them safe.Bare feet are allowed, but wipe them first.No unexpected parties, please – unless with Gandalf and company. ![]() Now, one does not simply walk into Middle-earth.
![]() ![]() ![]() In fact, norepinephrine, also known as noradrenalin, may sound familiar because it plays a large role in the fight or flight response, which kicks into high gear when we’re stressed and keeps us alert. These chemicals make us giddy, energetic, and euphoric, even leading to decreased appetite and insomnia – which means you actually can be so “in love” that you can’t eat and can’t sleep. High levels of dopamine and a related hormone, norepinephrine, are released during attraction. In this case, these things include spending time with loved ones and having sex. Attraction involves the brain pathways that control “reward” behavior (Figure 1), which partly explains why the first few weeks or months of a relationship can be so exhilarating and even all-consuming.ĭopamine, produced by the hypothalamus, is a particularly well-publicized player in the brain’s reward pathway – it’s released when we do things that feel good to us. While we can certainly lust for someone we are attracted to, and vice versa, one can happen without the other. Meanwhile, attraction seems to be a distinct, though closely related, phenomenon. Lust and attraction shut off the prefrontal cortex of the brain, which includes rational behavior. D: Several of the regions of the brain that affect love. B and C: Dopamine, oxytocin, and vasopressin are all made in the hypothalamus, a region of the brain that controls many vital functions as well as emotion. Figure 1: A: The testes and ovaries secrete the sex hormones testosterone and estrogen, driving sexual desire. ![]() The effects are less pronounced with estrogen, but some women report being more sexually motivated around the time they ovulate, when estrogen levels are highest. As it turns out, testosterone increases libido in just about everyone. While these chemicals are often stereotyped as being “male” and “female,” respectively, both play a role in men and women. The hypothalamus of the brain plays a big role in this, stimulating the production of the sex hormones testosterone and estrogen from the testes and ovaries (Figure 1). Through reproduction, organisms pass on their genes, and thus contribute to the perpetuation of their species. The evolutionary basis for this stems from our need to reproduce, a need shared among all living things. Lust is driven by the desire for sexual gratification. Testosterone and estrogen drive lust dopamine, norepinephrine, and serotonin create attraction and oxytocin and vasopressin mediate attachment. Though there are overlaps and subtleties to each, each type is characterized by its own set of hormones. Table 1: Love can be distilled into three categories: lust, attraction, and attachment. Each category is characterized by its own set of hormones stemming from the brain (Table 1). ![]() Helen Fisher at Rutgers, romantic love can be broken down into three categories: lust, attraction, and attachment. As it turns out, love is all about the brain – which, in turn, makes the rest of your body go haywire.Īccording to a team of scientists led by Dr. It’s no surprise that, for centuries, people thought love (and most other emotions, for that matter) arose from the heart. And chances are, your heart was thudding in your chest. You may have stammered, your palms may have sweated you may have said something incredibly asinine and tripped spectacularly while trying to saunter away (or is that just me?). Think of the last time you ran into someone you find attractive. So, if there’s really a “formula” for love, what is it, and what does it mean? Total Eclipse of the Brain What we do know, however, is that much of love can be explained by chemistry. Needless to say, the scientific basis of love is often sensationalized, and as with most science, we don’t know enough to draw firm conclusions about every piece of the puzzle. Google the phrase “biology of love” and you’ll get answers that run the gamut of accuracy. It turns out the science behind love is both simpler and more complex than we might think. Scientists in fields ranging from anthropology to neuroscience have been asking this same question (albeit less eloquently) for decades. ![]() ![]() ![]() We never target you for ads and prevent other companies from tracking you when you use our app. Read our privacy policy to understand your options to manage your data. We put privacy first in all the things we do at Edison Software including providing you with a secure and private email app. Privacy By Design is Our Promise to Our Users bill and receipts, entertainment, travel, and package alerts) are currently limited to US, UK, Canada, Australia, and India only. **Please note select assistant features (i.e. *Support for Exchange 2010 Service Pack 2 and above. Interactive push notification & customizable swipes.Swipe the blue unread dot to mark as read.Get alerts when the price of a recently purchased item drops and save some change. Never have to re-write the same message again. Send something prematurely or to the wrong person? Quickly and easily undo it. See your upcoming meetings, smart unsubscribe suggestions, and more at a glance. Īll of your most important travel, entertainment, receipts and purchases organized at a glance.The Most Intelligent Personal Assistant.One-tap unsubscribe, Block Sender, and bulk delete cleans your inbox in seconds. Read receipts get blocked at the door, so no privacy-invading tracking pixels can see what you do in your inbox. View your mailbox in a sleek, dark palette at night to spare your eyes from harsh blue light. Validate Contacts discovers new or changed contact information as it enters your mailbox.įind valid LinkedIn profiles through LinkedIn DiscoveryĬarefully tuned for unparalleled speed, so you’re not sitting around tapping your toes. Inbox Caller ID discovers and recognizes contact information from email signatures and informs you when they call or text. Spam Blocker gives you the power to permanently block calls and texts from bothersome email junk senders. Verify Sender proactively warns you of danger as suspicious emails enter your inbox. Please note we do NOT support POP.Īdd up to 5 additional people to your Plus plan for FREE. ![]() Edison Mail was crafted to make your email experience faster and better organized than ever before.Įmail supports Outlook, Yahoo, Hotmail, iCloud, Office/ Outlook 365, Exchange, AOL, Gmail, and IMAP* mail accounts, and is supported on iPhone and iPad. Lightning fast, intuitively designed, simple UI. Welcome to unparalleled speed, no ads, less spam, and all your email accounts in one place. "Faster than Gmail, faster than Outlook" -Walt Mossberg Verge "Unsubscribe with just a tap!" -TechCrunch ![]() "The way to go if you own an iPhone" -Business Insider ![]() ![]() It came in the form of magical items sealed away in a faraway place known as the "Elements of Harmony". Out of guilt, the purple unicorn decided to stay for brunch with them.Īt the celebration, Applejack was present to witness the return of Nightmare Moon where she had to stop Rainbow Dash and Pinkie Pie from doing anything stupid in the presence of this dangerous villain.Īpplejack along with the rest of the Mane Six arrived at Golden Oak library to learn about the method to defeat this new threat. Eventually that compilation came to an end though due to her tight schedule, Twilight needed to leave early, much to the dismay of the whole family. Said samples eventually began to pile up due to the sheer size of the apple family still alive in the present. Learning that the two are here to check up on the catering service, she called her family in, introducing each of them while they brought in samples for the foods that'll be served. There they got to witness the amazing feat of applebucking and Southern accent from the orange pony herself. My Little Pony: Friendship is Magic Season 1 Friendship is MagicĪpplejack's first appearance was during Twilight Sparkle and Spike's visit to Sweet Apple Acres. Once there she realizes that she truly belonged there, and finally gains her cutie mark. The rainbow left in the wake of Rainbow Dash's Sonic Rainboom leads her to return home to the farm. Once there, however, she finds it hard to fit in and becomes terribly homesick. Due to this, she decided to leave the farm to live with her upper-class relations, the Oranges, in the big city called Manehatten. ![]() 1.2.3.10 Just for Sidekicks/Games Ponies PlaysĪpplejack was the last one in her class to get her cutie mark, a trait that seems to run in the family. ![]() 1.2.2.15 MMMYstery on the Friendship Express. ![]() 1.2.2.11 The Super Speedy Cider Squeezy 6000.1.2 My Little Pony: Friendship is Magic. ![]() |